RELATIONSHIP BETWEEN WARM ISCHEMIC TIME AND RESISTIVE INDEX ON CREATININ REDUCTION RATIO DAY TWO AFTER LIVING KIDNEY DONOR TRANSPLANTATION
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Submitted
28 October 2021
Published
27 December 2021
Keywords:
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Warm ischemic time, restrictive index, creatinine reduction ratio, immediate graft function, delayed graft function
Abstract
Kidney transplantation (KT) may improve kidney function, via filtration, excretion, and hormonal function better than other kidney replacement therapies. Many factors may cause graft rejection or delayed graft function which may decrease the prognosis for graft survival. This study aims to determine associated factors of serum creatinine reduction ratio day 2 (CRR2) after living kidney donor transplants. This research used a retrospective cohort study design, with total sampling based on complete documents was done. A total 44 respondents (from 2012 to January 2020) and 22 respondents (based on the complete Resistive Index (RI) were recorded since 2018). Early Graft Function was defined using CRR2. Immediate Graft Function (IGF) was defined if CRR2 > 30% and Delayed Graft Function (DGF) if CRR2 ≤ 30%. The results of Multiple logistic regression analysis from 44 samples showed that Warm Ischemic Time (WIT) ≤ 40 minutes was significantly associated with IGF (OR 10.78; 95%CI: 1.66 to 70.16; p=0.01). A result with 22 samples showed that, only RI ≤ 0.7was significantly associated with IGF (OR 0.11; 95%CI: 0.03-0.41; p=0.002). In conclusion, WIT and RI influence on EGF with parameters CRR2 of living-donors. KT Patients with WIT ≤40 minutes and RI ≤0.7 had a higher risk of IGF.
References
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Vilar, E., Varagunam, M., Yaqoob, M. M., Raftery, M., & Thuraisingham, R. (2010). Creatinine reduction ratio: a useful marker to identify medium and high-risk renal transplants. Transplantation, 89(1), 97–103.
Zachary, A. A., & Leffell, M. S. (2016). HLA Mismatching Strategies for Solid Organ Transplantation - A Balancing Act. Front Immunol, 7(575).
Bellos, I., Perrea, D. N., & Kontzoglou, K. (2019). Renal resistive index as a predictive factor of delayed graft function: A meta-analysis. Transplant Rev (Orlando), 33(3), 145–153.
Enhesari, A., Mardpour, S., Makki, Z., & Mardpour, S. (2014). Early ultrasound assessment of renal transplantation as the valuable biomarker of long lasting graft survival: a cross-sectional study. Iran J Radiol, 11(1).
Farouk, S., Zhang, Z., & Menon, M. C. (2020). Non-HLA donor-recipient mismatches in kidney transplantation-A stone left unturned. Am J Transplant, 20(1), 19–24.
Ferede, A. A., Walsh, A. L., Davis, N. F., Smyth, G., Mohan, P., Power, R., Forde, J., O’Kelly, P., & Llittle, D. (2020). Warm Ischemia Time at Vascular Anastomosis is an Independent Predictor for Delayed Graft Function in Kidney Transplant Recipients. Exp Clin Transplant, 18(1), 13–18.
Heylen, L., Naesens, M., Jochmans, I., Monbaliu, D., Lerut, E., Claes, K., Heye, S., Verhamme, P., Coosemans, W., Bammens, B., Evenepoel, P., Meijers, B., Kuypers, D., Sprangers, B., & Pirenne, J. (2015). The effect of anastomosis time on outcome in recipients of kidneys donated after brain death: a cohort study. Am J Transplant, 15(11), 2900–2907.
Ho, C. H., Lan, C. W., Liao, C. Y., Hung, S. C., Li, H. Y., & Sung, Y. J. (2018). Mesenchymal stem cells and their conditioned medium can enhance the repair of uterine defects in a rat model. Journal of the Chinese Medical Association, 81(3), 268–276. https://doi.org/10.1016/j.jcma.2017.03.013
Kamińska, D., Kościelska-Kasprzak, K., Chudoba, P., Hałoń, A., Mazanowska, O., Gomółkiewicz, A., Dzięgiel, P., Drulis-Fajdasz, D., Myszka, M., Lepiesza, A., Polak, W., Boratyńska, M., & Klinger, M. (2016). The influence of warm ischemia elimination on kidney injury during transplantation - clinical and molecular study. Sci Rep, 6.
kemenkes RI. (2013). Riset kesehatan dasar (K. K. R. Indonesia (ed.)).
Khan, T. F. T., Ahmad, N., Serageldeen, A. S., & Fourtounas, K. (2019). Implantation Warm Ischemia Time in Kidney Transplant Recipients: Defining Its Limits and Impact on Early Graft Function. Ann Transplant, 24, 432–438.
Khan, T. F. T., Mirza, I., Rashid, T., & Anwar, N. (2020). Unrelated donors in kidney transplantation: Myths and the gruesome reality. Saudi Journal of Kidney Desease and Transplantation, 31(2), 563–567.
Kim, J. J., Fuggle, S. V, & Marks, S. D. (2021). Does HLA matching matter in the modern era of renal transplantation? Pediatr Nephrol, 36(1), 31–40.
Lemoine, M., Beauport, D. T., Lobbedez, T., Choukroun, G., Ligny, B. H. de, Hazzan, M., Guerrot, D., & Bertrand, D. (2019). Risk Factors for Early Graft Failure and Death After Kidney Transplantation in Recipients Older Than 70 Years. Kidney Int Rep, 4(5), 656–666.
Mocny, G., Bachul, P., Chang, E.-S., & Kulig, P. (2016). The value of Doppler ultrasound in predicting delayed graft function occurrence after kidney transplantation. Folia Med Cracov, 56(4), 51–62.
Nugroho, E. A., Hidayat, A., & Hidayat, A. T. (2019). Correlation Between Total Ischemic Time with Creatinin Level and Urine Production in Kidney Transplant : A Single Centre Report. Novel Research in Sciences, 1(1).
Pita-Fernández, S., Valdés-Cañedo, F., Seoane-Pillado, T., Lorenzo-Aguiar, D., Oliver-Garcia, J., Blanco-Castro, N., Seijo-Bestilleiro, R., & Pértega-Díaz, S. (2010). Influence of early graft function after renal transplantation and its impact on long-term graft and patient survival. Transplant Proc, 42(8), 2856–2858.
Rodrigo, E., Ruiz, J. C., Piñera, C., Fernández-Fresnedo, G., Escallada, R., Palomar, R., Cotorruelo, J. G., Zubimendi, J. A., Francisco, A. L. M. de, & Arias, M. (2007). Creatinine reduction ratio on post-transplant day two as criterion in defining delayed graft function. Am J Transplant, 4(7), 1163–1169.
Sieńko, J., Wiśniewska, M., Ostrowski, M., Ciechanowski, K., Safranow, K., Chudyk, A., Fronczyk, A., Rózański, J., Kamiński, M., Sulikowski, T., Romanowski, M., Pabisiak, K., Paczkowski, M., & Mizerski, A. (2003). Factors that impact on immediate graft function in patients after renal transplantation. Transplant Proc, 35(6), 2153–2154.
Tirtayasa, P. M. W., Duarsa, G. W. K., Situmorang, G. R., Yudiana, I. W., Santosa, K. B., Oka, A. A. G., Rodjani, A., & Rasyid, N. (2019). Association between Early Resistive Index Measurement and Early Graft Function and Long-Term Graft Survival after Kidney Transplantation: an Evidence-based Clinical Review. Acta Med Indones, 51(1), 77–85.
Vilar, E., Varagunam, M., Yaqoob, M. M., Raftery, M., & Thuraisingham, R. (2010). Creatinine reduction ratio: a useful marker to identify medium and high-risk renal transplants. Transplantation, 89(1), 97–103.
Zachary, A. A., & Leffell, M. S. (2016). HLA Mismatching Strategies for Solid Organ Transplantation - A Balancing Act. Front Immunol, 7(575).
Authors
Lusito, Nurani, A., Partiningrum, D. L. ., Arwanto, A., Lestariningsih, & Chasani, S. (2021). RELATIONSHIP BETWEEN WARM ISCHEMIC TIME AND RESISTIVE INDEX ON CREATININ REDUCTION RATIO DAY TWO AFTER LIVING KIDNEY DONOR TRANSPLANTATION. Journal of Midwifery and Health Science of Sultan Agung, 1(1), 1–13. https://doi.org/10.30659/jmhsa.v1i1.4
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